Some patients have a high-risk for developing breast cancer due to inherited gene mutation (such as, BRCA1, BRCA2, ATM, PALB2, TP53, CHEK2, CDH1 mutations) or a significant family history of breast and other cancers. Risk reducing mastectomy (RRM)in these patients can significantly reduce their individual risks to below population risk. The usual age group where RRM is most beneficial is before the age of 50-55 as the age-related risk trends down towards population risk by the age of 60.